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Urine organic anion increases with age and its effects on renal acid excretion vary with pKa

Year: 2025

Type: article

Abstract: When assessed using the kidney as a reporter organ, titrated urine anions behave overall as an acid load. However, those in the pKa range of 2.70-3.60 account for much of that behavior, whereas anions in the pKa ranges above 3.60 variably behave as alkali or acid, indicating that the urinary anions are heterogeneous. Despite their differences in function, they all rise with age. This may explain acid stress reported as part of the aging phenotype.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00147.2025

Authors: Priya M. Rawal, Yasin R. Badawy, Elaine M. Worcester, Fredric L. Coe, Megan Prochaska

Institution: University of Chicago

Language: English

Topic: Renal function and acid-base balance

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1706972244, Pathogenesis of Calcium Nephrolithiasis, Mechanisms of disordered citrate and oxalate excretion in nephrolithiasis