TEMPO-Catalyzed Electrochemical Hydrobenzylation of Imines with Methylarenes via Radical Cascade Reaction
Year: 2025
Type: article
Abstract: Herein, we report a TEMPO-catalyzed electrochemical protocol for the hydrobenzylation of imines using methylarenes that afford diverse α-benzylated amines. The present strategy features mild and metal-free conditions, the utilization of inexpensive chemical reagents, and good atomic economy. The reaction exhibits broad substrate tolerance, successfully accommodating imines bearing heterocyclic motifs and complex natural product-derived macromolecular frameworks. Mechanistic studies reveal a radical-mediated cascade pathway underlying the transformation.
Source: The Journal of Organic Chemistry
Authors: Kaifa Zhang, Kun Xia, Hui Chen, Yu Li, Ziwei Shan, Shuangming Zhang, Lei Zhou, Ablimit Abdukader
Institutions: Xinjiang University, Sun Yat-sen University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4414649984