Work

A Lyt at the end of the tunnel? Unraveling the complex interactions of the N -acetylglucosaminidase LytG in cell wall metabolism

Year: 2025

Type: article

Abstract: knockout, which does not exhibit these phenotypes. Cell-wall labelling with a fluorescent d-amino acid and muropeptide analysis has highlighted a functional connection between LytG, the carboxypeptidase DacA, and d,d-endopeptidases. These results highlight the use of chemical probes such as masarimycin to inform on the biological function of autolysins by providing insight into the role LytG plays in cell growth and division.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00151j

Authors: Jazmeen Hernandez, Jett Duval, Taryn Rauff, Ethan Hall, Mika Gallati, Brad A. Haubrich, Monica Thoma, Elimelec Aponte, Amit Basu, Joseph A. DeGiorgis, Christopher W. Reid

Institutions: Bryant University, Touro University Nevada, Brown University, Marine Biological Laboratory, Providence College

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: National Science Foundation, Brown University, National Institutes of Health, National Center for Research Resources, Division of Chemistry

Awards: G2319297766, RUI: Expanding the chemical biology toolbox for studying peptidoglycan metabolism, G5262008889

OpenAlex ID: W4414650889

FWCI:

Cites: 63

Cited by:

Related to: