LED photobiomodulation: From dermatological care to neuroprotection and pain management – review
Year: 2025
Type: article
Abstract: Photobiomodulation (PBM) using LED light in the red (600–650 nm) and blue (400–495 nm) spectra is a promising non-invasive approach in aesthetic and dermatological treatments. This study reviews PBM’s effects, focusing on red light’s deeper skin penetration that stimulates mitochondrial cytochrome c oxidase, enhancing ATP production, fibroblast proliferation, and collagen synthesis, which supports anti-aging and reduces inflammation. Blue light activates porphyrins, exhibiting antibacterial properties effective against acne. However, in darker skin phototypes (Fitzpatrick IV–VI), blue light may worsen hyperpigmentation through Opsin-3–mediated melanogenesis. Additionally, PBM benefits mood and sleep by improving neuronal metabolism and cerebral blood flow. The review compares LED-based PBM, which is safer and more accessible for home use, with laser-based PBM, offering higher precision. Current studies show promising clinical results but highlight the need for optimized treatment protocols and long-term outcome assessments.
Source: Our Dermatology Online
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414664185
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