Work

Recurrent Hormone Receptor–Positive Breast Cancer With Multiple Sites of Distant Metastasis: A Case Report and Review of the Literature

Year: 2025

Type: article

Abstract: Breast cancer is one of the most common malignancies and the leading cause of cancer-related mortality among women worldwide, with hormone receptor-positive (HR+) breast cancer being the most common subtype. Current guidelines recommend endocrine therapy as the first-line treatment for HR+, human epidermal growth factor Receptor 2-negative breast cancer. In this case report, we describe a patient with HR+ breast cancer who developed bone and liver metastases after breast cancer surgery. We document the disease progression from initial treatment to managing local recurrence and treating distant metastasis using salvage chemotherapy combined with endocrine therapy. Importantly, following denosumab treatment, the patient experienced a bone flare; this presented as increased radionuclide uptake on bone scans, but was later confirmed as pseudoprogression. Furthermore, we note changes in the patient's pathology as the disease progresses.

Source: International Journal of Breast Cancer

DOI: 10.1155/ijbc/5325167

Authors: Lu Li, Hui Liu, Xiangxin Huang, Haojun Luo

Institutions: Second Affiliated Hospital of Chongqing Medical University, Chinese Academy of Sciences, University of Chinese Academy of Sciences

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000