Seroprevalence of Nipah virus and related paramyxoviruses in native frugivorous bats, Luzon, Philippines
Year: 2025
Type: article
Abstract: Nipah virus (NiV) is a highly virulent zoonotic virus classified as a priority pathogen and biohazard. In 2014, an outbreak of NiV-like disease in the Province of Sultan Kudarat, Mindanao, Philippines resulted in a 53% case fatality rate. Here, we identified wildlife bat hosts of NiV by conducting monthly serological surveillance of flying foxes and other native frugivorous bat species across Luzon. We estimated 13.92% NiV seroprevalence in native flying foxes. We also detected NiV neutralizing activity in some flying fox sera and identified factors such as age and seasonality as drivers of high anti-NiV antibody levels. In contrast, less than 10% NiV seroprevalence was detected in R. amplexicaudatus, C. luzoniensis, and P. jagori bats, and these bats have no detectable neutralizing antibodies. This is the first serological description of NiV in native flying foxes in the Philippines, highlighting a major wildlife host in an understudied region.
Source: Emerging Microbes & Infections
Authors: Marana S. Rekedal, Mary-Glazel Noroña, Jairue Azel P. Café, Neil Mittal, Sophie A. Borthwick, Kirk J. Taray, Jezryl Jaeger L. Garcia, Samantha L. Magsanoc, Hazel R. Cruz, Dorothy Jane Manzano, Lianying Yan, Dolyce H. W. Low, David T. S. Hayman, Mary Grace Dacuma, Catalino Demetria, Phillip A. Alviola, Fedelino F. Malbas, Gavin J. D. Smith, Eric D. Laing
Language: English
Topic: Virology and Viral Diseases
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,643
Award: G6541015203
OpenAlex ID: W4414679098