Work

Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle

Year: 2025

Type: article

Abstract: Evans blue dye uptake and the release of creatine kinase (CK), the gold standard marker of muscle damage. These findings demonstrate the feasibility of using Myo-MOVES to induce and study functionally relevant disease phenotypes in DMD 3D skeletal muscle tissues. These results highlight the system's potential as a valuable tool for future applications in the field of 3D skeletal muscle tissue engineering, including drug screening and the study of DMD therapies and other muscular diseases.

Source: Lab on a Chip

DOI: 10.1039/d5lc00614g

Authors: Martín Ruiz-Gutiérrez, Ainoa Tejedera-Villafranca, Sergi Pujol-Pinto, Javier Ramón-Azcón, Juan M. Fernández-Costa

Institutions: Barcelona Institute of Science and Technology, Institute for Bioengineering of Catalonia, Universitat de Barcelona, Institució Catalana de Recerca i Estudis Avançats

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid