Work

Quantifying the risk of drug-associated skin hyperpigmentation relative to the general population: A national cohort study using TriNetX

Year: 2025

Type: article

Abstract: To the Editor: While multiple drugs have been linked to hyperpigmentation, data quantifying conferred risk remain limited.1 This study quantifies background prevalence of hyperpigmentation in the general population and estimates the additional risk associated with 6 medications commonly implicated in drug-induced hyperpigmentation (DIH): doxycycline, minocycline, phenytoin, carbamazepine, amitriptyline, and hydrochlorothiazide. Analyses were conducted using TriNetX (105 health care organizations; Supplementary Methods, available via Mendeley at https://data.mendeley.com/datasets/scsbz22jmt/1).

Source: JAAD International

DOI: 10.1016/j.jdin.2025.08.011