Late-stage diagnosis and its impact on survival in Pakistani women with cervical cancer: Findings from an institutional cancer registry
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: This study aimed to analyze mean age, clinicopathological characteristics, and survival rates of cervical cancer patients in Karachi, Pakistan. Methodology: A retrospective cohort study was conducted using data from the Cancer Registry at Aga Khan University Hospital (AKUH) between January 1, 2010 to December 31, 2020. Kaplan-Meier estimates were used to calculate one-, three-, and five-year survival rates. Cox proportional hazards regression was employed to identify factors associated with survival. The analysis included 310 women diagnosed with primary cervical cancer between 2010 and 2020. Results: The mean age at diagnosis was 51.3 years (SD ± 11.3), with most women (83.9%) diagnosed at an advanced stage. Kaplan-Meier survival analysis revealed an overall mean survival time of 176.3 months (SD 18.1), with one-, three-, and five- years survival rates of 86.6%, 78.5%, and 54.4%, respectively. Cox proportional hazards regression identified late-stage diagnosis (HR = 3.64, 95% CI: 1.25-10.59) and smoking history (HR = 3.37, 95% CI: 1.27-8.97) as independent predictors of poorer survival. Conclusion: Aga Khan University Hospital (AKUH), adjusted hazard ratios (aHR), confidence intervals (CI), Standard Deviation (SD), Interquartile Range (IQR), Hazard Ratio (HR), Human Papillomavirus (HPV), age standardized incidence rate (ASIR), World Health Organization (WHO), Lower Middle-Income Countries (LMICs), Squamous cell carcinoma (SCC), American Joint Committee on Cancer (AJCC).
Authors: Uzma Shamsi, Sarah Saleem, Namra Usman, Iqbal Azam, Aziz Aliya
Institutions: Aga Khan University, Aga Khan University Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $400
OpenAlex ID: W4414704379
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