CHAF1B: the hidden culprit behind sorafenib resistance in hepatocellular carcinoma
Year: 2025
Type: article
Abstract: CHAF1B is a key regulator of sorafenib resistance, and targeting CHAF1B in conjunction with sorafenib may represent a promising therapeutic approach for HCC by modulating the PI3K/Akt/HIF-1α signaling axis.
DOI: 10.7150/ijms.118471
Authors: Wenfeng Zhuo, Jiali Zhao, Zhouying Zheng, Shanglin Cai, Guifang Zeng, En Lin, Zirui Bai, Bo Wang, Yingbin Jia, Peiping Li, Jian Li
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4414708002