STK32C as a Therapeutic Target in Colorectal Cancer via HSP90-PI3K/AKT/mTOR Signaling
Year: 2025
Type: article
Abstract: , STK32C depletion reduced the growth of HCT116 cells in BALB/c mice with decreased expression of STK32C, HSP90, PCNA, and AKT and activated caspase 3. Overall, these findings suggest STK32C as a novel oncogenic driver in CRC that modulates HSP90 and PI3K/AKT/mTOR signaling and highlights its potential as a therapeutic target alone or in combination with 5-FU.
DOI: 10.7150/ijbs.121647
Authors: Chi-Hoon Ahn, Ji Eon Park, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim
Institutions: Kyung Hee University, South Baylo University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4414708103