Comparative analysis of the 5-HTTLPR polymorphism of SLC6A4 gene in Russian and Yakut populations
Year: 2025
Type: article
Study design: Observational Study
Abstract: The 5-HTTLPR polymorphism of the SLC6A4 gene plays a key role in the regulation of serotonergic transmission and may influence susceptibility to anxiety and depressive disorders. This study presents a comparative analysis of the distribution of genotypes and alleles of this polymorphism in representatives of the Russian (n = 250) and Yakut (n = 260) ethnic groups. A significantly higher prevalence of the S allele (77.7%) and the homozygous SS genotype (63.8%) was observed in the Yakut population compared to the Russian group (44.8% and 20.8%, respectively; p < 0.001). The Russian sample was characterized by a higher frequency of the L allele and the SL genotype. The identified differences reflect the high frequency of the S allele characteristic of the Indigenous peoples of Siberia and underscore the ethnic specificity of genetic factors involved in psycho-emotional regulation.
Source: Yakut Medical Journal
Authors: A. V. Krylov, N. I. Pavlova, A. A. Bochurov
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414708111