Gli1 regulates fibro/adipogenic progenitor function through modulation of Ido1 in muscle regeneration
Year: 2025
Type: article
Abstract: assays confirmed enhanced lipid droplet formation under adipogenic conditions. Mechanistically, Gli1 directly activates the transcription of the key metabolic enzyme indoleamine 2,3-dioxygenase 1 (Ido1), and inhibition or knockdown of Ido1 phenocopied the effects of Gli1 loss. Together, these findings uncover a previously unrecognized role for Gli1 in orchestrating muscle regeneration by modulating FAP fate and function, providing new insights into the cellular and molecular framework governing muscle repair.
DOI: 10.7150/ijbs.116134
Authors: Lili Han, Fengmin Zhang, Jujin Zhang, Xiaonan Li, Kunpeng Wang, Biao Liu, Jiawen Song, Xinyan Liu, Yun Qian, Kai Li, Yingnan Lei, Claudia Spits, Yi Chang, Chengle Zhuang, Zhen Yu, Yun Zhao, Jiayin Peng
Institutions: Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Tongji University, Shanghai Tenth People's Hospital, Vrije Universiteit Brussel, Yangpu Hospital of Tongji University, Shanghai Jiao Tong University, Renji Hospital, ShanghaiTech University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4414708268