METTL3-mediated m6A methylation on lncRNA H19 inhibits intrahepatic cholangiocarcinoma progression through PPARγ downregulation
Year: 2025
Type: article
Abstract: . Collectively, these findings identify METTL3-mediated m6A modification of H19 as a critical suppressor of ICCA progression through modulation of PPARγ signaling. One interesting treatment option for ICCA may be the use of H19-armed oncolytic adenoviruses, especially when combined with PPARγ suppression.
DOI: 10.7150/ijbs.120413
Authors: Rong Xiao, Xinya Lu, Fang Huang, Yaru Zhao, Hao Jin, Xiaoyuan Jia, Biao Huang, Yigang Wang, Liang Chu
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4414710179