Work

Gut microbial signatures in autoimmune hepatitis: unlocking diagnostic and therapeutic potential

Year: 2025

Type: article

Abstract: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with unclear etiology but likely results from a complex interplay of genetic susceptibility and environmental triggers. Emerging evidence highlights the role of gut microbiota in AIH pathogenesis, with specific genera such as Veillonella, Lactobacillus, and Oscillospira demonstrating diagnostic value. Dysbiosis-associated biomarkers like lipopolysaccharide and aspartate aminotransferase further support a microbial role in disease onset and progression. Despite these promising developments, rare AIH variants remain poorly characterized due to methodological and population-level limitations. Moving forward, large-scale, longitudinal studies integrating metagenomics, metabolomics, and host genomic data are needed to establish subtype-specific microbial markers and assess the efficacy of targeted interventions such as probiotics and bacteriophage therapy.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000003709

Authors: Fatima Iftikhar, Aliha Iftikhar, Maliha Khalid, Muhammad Talha, Aminath Waafira

Institutions: Liaquat National Hospital, Jinnah Sindh Medical University, King Edward Medical University, Maldives National University

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850