Year: 2025
Type: article
Abstract: Autoimmune anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis (AAV) and glomerulonephritis is characterized by the presence of autoantibodies (so-called ANCA), which, by binding to the body's own antigens, lead to damaged blood vessels (vasculitis) and subsequently to organ damage, particularly of the kidneys. The primary endogenous antigens are the enzymes proteinase 3 (PR3) and myeloperoxidase (MPO) expressed by neutrophil granulocytes and monocytes. In addition to the autoantibodies, both T-cellular response to those autoantigens and monocyte/macrophage-mediated processes play a decisive role. Since conventional therapy is based on the widespread suppression of the immune system, susceptibility to infections or the development of cancer are possible side effects. Furthermore, not all patients respond to conventional therapy or, despite responding at first, suffer multiple relapses. Therefore, there is a need for alternative treatment strategies and one promising option is the use of CD19-targeting chimeric antigen receptor (CAR)-T cells.
Source: Clinical Kidney Journal
DOI: 10.1093/ckj/sfaf290
Authors: Dörte Lodka, Adrian Schreiber
Institutions: Max Delbrück Center, Charité - Universitätsmedizin Berlin
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,335
OpenAlex ID: W4414726117