Identifying clustering in patterns of late effects among survivors of adolescent and young adult Hodgkin lymphoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We examined late effects clustering among adolescent and young adult (AYA; age 15-39 years at diagnosis) Hodgkin lymphoma (HL) survivors and identified characteristics associated with each cluster. METHODS: We included AYAs with HL in 2006-2018 from the California and Utah Cancer Registries linked to statewide hospitalization, emergency department, and ambulatory surgery visit data. We identified severe late effects >2 years after cancer diagnosis in 9 late effects categories. Latent class analysis (LCA) was used to identify late effects clusters. Multinomial logistic regression models estimated adjusted associations of demographic and treatment characteristics with LCA late effect group. RESULTS: We identified 4635 AYA HL survivors with median follow-up of 8.2 years and 4 late effects groups: 77.1% had a low probability of any late effect (Low Morbidity), 12.8% had high probability of Thyroid disorders, 8.0% had high probability of Cardiovascular Disease (CVD), and 2.1% had high probability of Multiple Conditions (CVD, diabetes/pancreatic, thyroid, and renal diseases). Publicly insured AYAs were more likely than those with private insurance to be in the CVD (OR = 1.53, 95% CI = 1.18 to 1.98) and Multiple Conditions (OR = 2.17, 95% CI = 1.29 to 3.66) than the Low Morbidity group. AYAs with radiation were more likely to be in the Multiple Conditions (OR = 2.31, 95% CI = 1.41 to 3.78) and Thyroid (OR = 2.81, 95% CI = 2.20 to 3.58) groups. Hematopoietic cell transplantation was associated with Multiple Conditions (OR = 9.50, 95% CI = 5.82 to 15.50), CVD (OR = 3.82, 95% CI = 2.96 to 4.93), and Thyroid (OR = 2.86, 95% CI = 2.12 to 3.85) groups. CONCLUSIONS: While most AYA HL survivors were in the Low Morbidity group, those with public insurance or intense treatment may be at higher risk for multiple conditions.
Source: JNCI Cancer Spectrum
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,050
Awards: G1666956106, G2337224928, G2995161194, G3351322984, G3987779641, G4771140405, G4878091559, G504639888, G5778816553, CANCER PREVENTION AND CONTROL PROGRAM 3: NATIONAL PROGRAM OF CANCER REGISTRIES - THE MISSION OF THE UTAH CANCER REGISTRY (UCR), AS AUTHORIZED BY THE UTAH CANCER REPORTING RULE, IS TO PROMOTE PUBLIC HEALTH BY COLLECTING AND MANAGING CANCER INCIDENCE AND MORTALITY DATA FOR THE STATE OF UTAH. UCR HAS OPERATED AS A STATEWIDE, POPULATION-BASED REGISTRY IN UTAH SINCE 1966. UCR JOINED THE NATIONAL PROGRAM OF CANCER REGISTRIES (NPCR) IN 2017. UCR DATA SUBMITTED TO CDC HAVE MET THE NATIONAL DATA QUALITY STANDARD FOR EACH YEAR OF OUR NPCR PARTICIPATION, AND THE REGISTRY HAS RECEIVED MULTIPLE ANNUAL AWARDS RECOGNIZING HIGHEST DATA QUALITY AS ASSESSED BY THE SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS PROGRAM (SEER) OF THE NATIONAL CANCER INSTITUTE AND BY THE NORTH AMERICAN ASSOCIATION OF CENTRAL CANCER REGISTRIES (NAACCR). IN THIS APPLICATION, THE UNIVERSITY OF UTAH REQUESTS SUPPORT FOR UCR UNDER CDC-RFA-DP22-2202 PROGRAM 3, NPCR. WE REQUEST THIS SUPPORT TO ENHANCE OUR SURVEILLANCE QUALITY, PERFORM PROGRAM MONITORING AND EVALUATION, AND COLLABORATE WITH PARTNERS IN CANCER CONTROL AND PREVENTION THROUGH DISSEMINATION OF DATA TO IMPROVE HEALTH EQUITY AND CANCER OUTCOMES. IN THIS APPLICATION, WE PRESENT A COMPREHENSIVE WORK PLAN THAT ENCOMPASSES ACTIVITIES TO ADDRESS THE FOUR APPLICABLE STRATEGIES OF THE NOTICE OF FUNDING OPPORTUNITY. A COMPREHENSIVE AND COORDINATED APPROACH IS VITAL TO DEVELOPING AND IMPLEMENTING STRATEGIES AND ACTIVITIES TO CONTROL AND PREVENT CANCER. UCR COLLABORATES CLOSELY WITH UTAH DEPARTMENT OF HEALTH (UDOH) CANCER PROGRAMS TO SUPPORT AND ADVANCE CANCER CONTROL AND PREVENTION IN UTAH THROUGH DISSEMINATION OF DATA AND PARTICIPATION IN JOINT PROJECTS AND INITIATIVES. IN THIS APPLICATION, WE PROPOSE ACTIVITIES THAT SUPPORT OUR COLLABORATORS’ PROGRAM PLANNING AND IMPLEMENTATION BY MAINTAINING OUR STRONG SURVEILLANCE INFRASTRUCTURE AND DISSEMINATING HIGH QUALITY DATA. WE ALSO PROPOSE TO COLLABORATE WITH OUR PARTNERS AT UDOH TO IMPLEMENT A POPULATION-BASED SURVEY OF CANCER SURVIVORS FOR SURVEILLANCE OF HEALTH IN THIS POPULATION AND IMPROVE HEALTH EQUITY. THROUGH THE PROPOSED ACTIVITIES, UCR WILL IMPROVE THE TIMELINESS, QUALITY, COMPLETENESS, AND CONFIDENTIALITY OF NPCR SURVEILLANCE DATA THROUGH RIGOROUS PROGRAM MONITORING AND INCREASED ADOPTION OF DATA MODERNIZATION STRATEGIES. WE WILL ALSO INCREASE COLLABORATION WITH OUR PUBLIC HEALTH PARTNERS AND THE DISSEMINATION OF USE OF SURVEILLANCE DATA., G7290139498, G8427953030, G946791773
OpenAlex ID: W4414726804