Work

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry

Year: 2025

Type: article

Abstract: We show that photochemical carbene labelling of the turkey β 1 -adrenergic receptor using a generic diazirine probe reveals binding of agonists and antagonists together with resulting conformational changes.

Source: Chemical Science

DOI: 10.1039/d5sc05107j

Authors: James R. Lloyd, Arppana S. Varughese, Parth Kapoor, Katharina L. Dürr, Hsin-Yung Yen, Ali Jazayeri, Jonathan T. S. Hopper, Neil J. Oldham

Institution: University of Nottingham

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Biotechnology and Biological Sciences Research Council

Awards: Nottingham DTP3, G2955572540, Nottingham-Rothamsted Doctoral Training Partnership, G933792555

OpenAlex ID: W4414732668

FWCI: 0.252

Cites: 29

Cited by: 1

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