Year: 2025
Type: article
Study design: Case Report
Abstract: Melanoma is the most aggressive form of common skin cancer and recurrence, while rare, typically presents as pigmented papules or nodules near the primary site. Here, we describe a case of a woman with stage IIIC melanoma undergoing intralesional talimogene laherparepvec (T-VEC) therapy who developed a spreading erythematous rash on her left leg, accompanied by fatigue and leg swelling. Skin biopsy revealed recurrent melanoma, with SOX10 and Melan-A positivity, and imaging showed features concerning for multifocal disease recurrence in the left popliteal fossa. This case highlights an unusual presentation of melanoma recurrence and underscores the importance of biopsy in -evaluating new skin findings in patients with a history of melanoma.
Source: Skin Health and Disease
Institutions: University of Utah, Huntsman Cancer Institute
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,597
OpenAlex ID: W4414737866