Year: 2025
Type: article
Abstract: Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) in cystic fibrosis (CF) impairs lung function and contributes to the progression of the disease. Optimal eradication regimens for new-onset MRSA infections in people with CF (pwCF) remain undefined. Materials and Methods: This prospective, multicenter study evaluated a standardized, step-up MRSA eradication regimen in pwCF with new-onset MRSA infections between 2020 and 2022. Results: Ninety-one pwCF (52.7% male, median age: 9 years) were included. Our treatment regimen included oral rifampicin and co-trimoxazole or oral rifampicin and fusidic acid. Intravenous teicoplanin treatment was initiated in patients whose clinical condition was unstable. The eradication success rates after 1 year were 82.4%, 92.9%, and 55.6%, respectively. No significant changes in median FEV1% predicted or BMI z -scores were observed between MRSA-eradicated and non-eradicated groups at baseline or 12 months. Conclusion: A standardized step-up MRSA eradication protocol is effective for new-onset MRSA infections in pwCF. Randomized controlled trials are needed to confirm these findings.
Source: Clinical Pediatrics
Authors: Aynur Guliyeva, Cansu Yilmaz Yegit, Muruvvet Yanaz, Mine Kalyoncu, Merve Selçuk Balci, Seyda Karabulut, Gamze Tastan, Burcu Uzunoglu, Hüseyin Arslan, Hakan Yazan, Gülay Bas Bilgin, Ayse Ayzıt Kılınc Sakallı, Almala Pinar Ergenekon, Saniye Girit, Erkan Cakır, Yasemin Gokdemir, Ela Erdem Eralp, Fazilet Karakoc, Bulent Karadag
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4414744046