Work

Thiazole peptidomimetics as chemical modulators of KRAS gene expression via G-quadruplex stabilization

Year: 2025

Type: article

Abstract: mRNA and protein levels in HeLa cells. This downregulation correlates with the inhibition of key downstream signaling pathways, including MAPK and Akt/mTOR, which are critical for cancer cell proliferation and survival. These results highlight the potential of G4-binding peptidomimetics as chemical tools for modulating oncogene expression through selective stabilization of promoter G-quadruplex structures.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00046g

Authors: Debasmita Biswas, Ananta Gorai, Sandip Maiti, Ritapa Chaudhuri, Sayantan Pradhan, Jyotirmayee Dash

Institution: Indian Association for the Cultivation of Science

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962