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Supplementary Figure S17 from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

Year: 2025

Type: supplementary-materials

Abstract: (A) Structure of CAIX targeted SMDC AAZ-GlyPro-MMAE (6). (B) Ex vivo MMAE-release biodistribution performed 24 hours after systemic administration of compound 6 in SK-RC-52.hFAP and SK-RC-52-wt tumor-bearing Balb/c nude mice (n = 2 animals/group).

DOI: 10.1158/1535-7163.30255236

Authors: Tony Georgiev, Sara Puglioli, Lucrezia Principi, Ettore Gilardoni, Christian Pellegrino, Gabriele Bassi, Andrea Galbiati, Dario Neri, Samuele Cazzamalli

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4414747833

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