Adipokine blood profile in young people with comorbid pathology
Year: 2025
Type: article
Study design: Observational Study
Abstract: The aim of study was to study the features of the adipokine blood profile in young people with comorbid pathology.Material and methods. A cross-sectional population survey of Novosibirsk was conducted. The population sample included 1415 people, including 47 % of men. Comorbid pathology was considered a combination of 3 or more pathological conditions (CHD, AG, CB, hyperLDL-C, decreased renal function and type 2 diabetes). Adipokine levels in the blood were determined using the multiplex analysis method on a Milliplex multiplex analyzer (Merck, Millipore).Results. When conducting a univariate logistic regression analysis, it was found that the presence of comorbid pathology was associated with an increase in amylin by 1 pg/ml (p < 0.0001), ghrelin by 1 pg/ml (p = 0.016), resistin by 1 ng/ml (p = 0.001), IL-6 by 1 pg/ml (p = 0.005), C-peptide by 1 ng/ml (p = 0.024) and a decrease in PYY by 1 pg/ml (p = 0.007). In multivariate regression analysis in model 1 (gender, age, OT, resistin, IL-6, and PYY), the chance of having comorbid pathology increased by 15 % with an increase in age by 1 year (p = 0.011) and by 2.5 % with a decrease in PYY by 1 pg/ml (p = 0.005); in model 2 (gender, age, WC, resistin, IL-6, and C-peptide), the chance of having a comorbid pathology increased by 13 % with an increase in age by 1 year (p = 0.001), by 0.1 % with an increase in resistin levels by 1 ng/ml (p = 0.046), by 12 % with an increase in IL-6 levels by 1 pg/ml (p = 0.041), and by 116 % with an increase in C-peptide levels by 1 ng/ml (p = 0.019).Conclusions. In young people, the presence of comorbid pathology is associated with an increase in the blood of amylin, ghrelin and a decrease in the level of PYY, responsible for appetite regulation, as well as with an increase in the levels of resistin, IL-6 and C-peptide, involved in the formation of insulin resistance.
Source: Ateroscleroz
Authors: A. D. Afanaseva, L. V. Shcherbakova, Ya. V. Polonskaya, E. V. Kashtanova, V. S. Shramko, D. V. Denisova, Yu. I. Ragino
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414749034