Work

Green Light Photobiomodulation: A Systematic Review of New Approaches for Treating Bone Repair

Year: 2025

Type: review

Abstract: Background: Green light photobiomodulation (GPBM, 500–565 nm) promotes tissue healing, reduces inflammation, and alleviates pain, with emerging potential in bone repair. This review evaluates GPBM’s therapeutic effects on bone-related cells (proliferation, differentiation, migration), inflammation, vascularization, and neuronal responses. Methods: We assessed the influence of different GPBM parameters, possible underlying molecular mechanisms, and prospects for in vivo applications based on available studies. Results: GPBM acts through mitochondria, opsins, and transient receptor potential vanilloid (TRPV) channels. The most effective irradiation method uses low irradiance (5.3–100 mW/cm 2 ) with a single exposure of ∼5 J/cm 2 . Excessively low irradiance is ineffective, while excessively high irradiance may cause inhibitory effects. GPBM enhances bone-related cell functions, suppresses inflammation, and promotes vascular and neuronal responses. Conclusions: GPBM shows promise for bone repair, but further research is needed to optimize parameters, clarify molecular mechanisms, and standardize clinical trial protocols to ensure reliable in vivo outcomes.

Source: Photobiomodulation Photomedicine and Laser Surgery

DOI: 10.1177/25785478251381479

Authors: Wentao Bao, Jingyun Zhuang, Fei Liu, Jingshan Hu, Xianxiong Chen, Yuxi Jiang

Institutions: Shenzhen University, Longgang Central Hospital

Language: English

Topic: Laser Applications in Dentistry and Medicine

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Basic and Applied Basic Research Foundation of Guangdong Province