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Refractory antibody-mediated rejection after high-emergency lung transplantation for dermatomyositis with anti-MDA5 antibody: a case report

Year: 2025

Type: article

Abstract: This case report describes a female with amyopathic anti-MDA5+ dermatomyositis who underwent emergency double lung transplantation due to rapidly progressive interstitial lung disease. Following transplantation, she developed acute antibody-mediated rejection (AMR). Despite multiple rounds of immunosuppressive therapy, her condition continued to deteriorate, and her donor-specific anti-human leukocyte antigen antibody levels increased markedly. An experimental treatment, imlifidase-an immunoglobulin G endopeptidase-was employed as a rescue therapy. This case highlights the complexity of posttransplant management of AMR and emphasizes the need for dedicated clinical trials to provide additional data.

Source: Clinical Transplantation and Research

DOI: 10.4285/ctr.25.0034

Authors: Louise Chantelot, Domitille Mouren, Jean-Luc Taupin, Aurélie Cazes, Jonathan Messika, Cendrine Godet, Mathilde Salpin, Gaelle Weisenburger, Brice Lortat-Jacob, Pierre Mordant, Jean-François Alexandra, Raphael Borie, Chloé Comarmond, Yves Allenbach, Yurdagül Uzunhan, Hervé Mal, Antoine Roux, Vincent Bunel

Institutions: Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Hôpital Saint-Louis, Hôpital Lariboisière, Sorbonne Université, Pitié-Salpêtrière Hospital, Université Sorbonne Paris Nord, Hôpital Avicenne, Hôpital Foch

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414751367

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