Gangrenous pyoderma, ulcerative form as a symptom of Crohn's disease: a clinical case
Year: 2025
Type: article
Study design: Case Report
Abstract: Pyoderma gangrenosum is a rare neutrophilic skin disease encountered in clinical practice by dermatovenerologists. This severe condition is characterized by the formation of painful ulcers with a necrotic component and is often associated with systemic diseases, such as inflammatory bowel pathologies, rheumatoid arthritis and hematological disorders. The etiology of the disease remains unclear, although modern studies indicate a key role of disorders in the immune system, including neutrophil dysregulation and cytokine imbalance. The article provides a detailed analysis of a clinical case of ulcerative pyoderma gangrenosum in a patient with Crohn's disease and multiple comorbidities. The features of the disease course in a patient with inflammatory bowel disease, rheumatoid arthritis and other systemic disorders are discussed. The importance of an interdisciplinary approach involving a dermatologist, rheumatologist and gastroenterologist for early diagnosis of the primary disease and development of optimal patient management tactics is emphasized. The treatment methods used, including local therapy, systemic glucocorticoids, biological therapy and correction of concomitant pathology, which led to regression of skin manifestations, are analyzed.
Authors: Larisa V. Tarasova, Nadezhda V. Krasnova, Republican Dermatovenerologic Dispensary, Cheboksary, Russia, Gelia G. Gimalieva, Republican Dermatovenerologic Dispensary, Cheboksary, Russia, Irina V. Koltsova, Republican Dermatovenerologic Dispensary, Cheboksary, Russia, Yulia V. Тsyganova
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414754843
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