Year: 2025
Type: article
Study design: Case Report
Abstract: Dermatopathia pigmentosa reticularis (DPR) is an exceptionally rare autosomal dominant ectodermal dysplasia resulting from mutations in the KRT14 gene.Herein, we present the case of a seventeen-year-old female patient with reticulate hyperpigmentation, non-scarring alopecia, onychodystrophy, and adermatoglyphia.Dermoscopy of the scalp showed decreased hair follicle density and dermoscopy of the neck showed brownish dots and globules in a reticular pattern.Histopathology of the palm revealed a sparse superficial perivascular infiltrate, mainly consisting of melanophages, along with some lymphocytes.This case underscores the importance of recognizing the characteristic clinical features of DPR, supported by dermoscopic and histopathological findings, to differentiate it from other reticulate pigmentary disorders.
Source: Our Dermatology Online
Authors: Sheenu Goyal, Sumir Kumar, Sameer Hundal, Arnav Mehta
Institution: Guru Gobind Singh Medical College and Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414759200