Year: 2025
Type: article
Abstract: Background: This study investigates establishing a novel therapeutic approach to treating peptic ulcers that uses an in-situ gel microsponge incorporating esomeprazole. Microsponges carrying esomeprazole magnesium, ethyl cellulose, and Eudragit RS-100 were developed via a quasi-emulsion solvent diffusion technique. Methods: Five formulations were developed and analyzed for entrapment efficiency, drug content, yield, and particle size. Results: From all the five formulations, the F3 formulation showed the maximum results in terms of high drug content (85.24%), entrapment efficacy (85.67 %), particle size (8.36±0.43 µm), and production yield (87.35%). Then the microsponges were incorporated with the Poloxamer 188 to form in-situ gel. The formulation (F3) demonstrated appropriate viscosity (38cps), gelling time (11.95±0.56 sec), and gelling capacity (++). The in-vitro drug release profile revealed that formulation F3 exhibited an extended drug release rate (92.18%). Stability studies indicated minimal changes in particle size (8.36±0.43) and entrapment efficiency (85.67) over three months. Conclusion: This innovative Esomeprazole-loaded microsponge in- situ gel formulation is promising to enhance drug delivery, prolong drug release, and improve patient compliance in peptic ulcer therapy. Keywords: Microsponge, Esomeprazole, Gastric, Peptic Ulcer, In-situ gel
Authors: Joshi Vineet, Raja Md. Hussain, Dobhal Kiran
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414778193
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