Year: 2025
Type: article
Abstract: The genus Magnolia, encompassing hundreds of globally distributed species, has a long-standing history in traditional medicine for treating diverse ailments. These species are particularly renowned for their rich array of bioactive compounds, notably alkaloids. This study provides a comprehensive summary of novel alkaloid compounds identified in various Magnolia species within recent years. Through a targeted literature review utilizing Google Scholar and PubMed (2002–2024), we pinpointed nine novel alkaloids and one nitrogen-based compound isolated from four distinct Magnolia species. These newly discovered compounds exhibited promising bioactivities, including significant antiplatelet and anti-acetylcholinesterase effects. Structurally, the majority of these compounds belong to the aporphine and benzylisoquinoline classes, although some display unique configurations, such as glycosidic or N-oxide alkaloids. This review aims to bridge a critical gap in the existing scientific literature regarding the comprehensive documentation of novel alkaloid secondary metabolites found across the diverse Magnolia genus.
Source: Borneo Journal of Pharmacy
Authors: Tegar Achsendo Yuniarta, Rosita Handayani
Institutions: University of Surabaya, Universitas Airlangga
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414778593