Work

Remote Diazenylation of Fluorinated Alkyl Iodides via 1,5-HAT

Year: 2025

Type: article

Abstract: Herein, we demonstrated a site-selective diazenylation of fluorinated alkyl iodides via 1,5-hydrogen atom transfer using diazonium salts, in combination with iron metal and ferrocene as an inexpensive catalytic system. The reactions proceeded under mild conditions with high regioselectivity, thereby enabling the efficient synthesis of a diverse range of azo compounds that have been difficult to access by traditional synthetic methods.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.c25-00506

Authors: Masahiro Abe, Akiho Mizukami, Aoi Hirata, Nagisa Yano, Airu Kataoka, Kiyofumi Inamoto

Institution: Mukogawa Women's University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Japan Society for the Promotion of Science

Awards: Development of environmentally friendly organic synthesis based on mechano-redox reactions, Development of Novel Catalytic C-H Cyclization Processes for Synthesis of Heterocycles