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Admission Blood Gas Variables and Electrolytes in Predicting Significant Endpoints in Intensive Care Unit Patients with Emerging Acute Kidney Injury

Year: 2025

Type: article

Abstract: Introduction: Acute kidney injury (AKI) is a prevalent issue in intensive care units (ICUs). There is a paucity of data regarding the use of blood gas and electrolyte measurements in predicting the risk of significant endpoints (kidney replacement therapy [KRT], death) in emerging, yet undiagnosed AKI. Methods: Retrospective, observational, single-center study. The study documented 4 admission electrolytes (serum sodium, potassium, ionized calcium, and phosphate) and 3 admission blood gas variables (arterial pH, actual bicarbonate, pCO2). The endpoints of the study were the need for KRT and death in the ICU. Results: A total of 213 patients were included in the study. The ICU mortality rate was 31%, and 22.5% of all subjects required at least one individual KRT session. There were significant differences in admission serum sodium and phosphate levels between survivors and non-survivors (both lower in survivors), and in arterial pH and actual bicarbonate levels (both higher in survivors). The majority of all tested variables were identified as independent predictors of either the need for KRT or ICU death. Conclusions: Integrating admission electrolytes and blood gas variables may potentially aid in identifying subsets of AKI patients at risk of death.

Source: Kidney & Blood Pressure Research

DOI: 10.1159/000548324

Authors: Baschar Khader, Rebecca Lehmann, Benedikt Marahrens, Oliver Ritter, Daniel Patschan

Institutions: Medizinische Hochschule Brandenburg Theodor Fontane, Universitätsklinikum Brandenburg an der Havel, University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,780