Work

Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells

Year: 2025

Type: article

Abstract: Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

Source: European Journal of Immunology

DOI: 10.1002/eji.70066

Authors: Kevin Schmid, Robin P. Schenk, Gabriela M. Wiedemann

Institutions: TUM Klinikum, Technical University of Munich

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,550