Work

Calculations of the Cell Survival Rate after Irradiating with Minibeams of Protons and 12C

Year: 2025

Type: article

Abstract: The propagation of minibeams of protons and $$^{{12}}$$ C in a water phantom was modelled with Geant4 v10.3, and the survival probabilities of human salivary gland cells representing healthy and tumour tissues of normal radiosensitivity were calculated with the modified microdosimetric kinetic model. The advantage of minibeams over homogeneous irradiation in sparing healthy tissues proximal to the tumour was demonstrated. Survival-volume histograms were proposed to quantify the difference in the survival probability of cells inside and outside the minibeam spots.

Source: Physics of Particles and Nuclei Letters

DOI: 10.1134/s1547477125701444

Authors: A. O. Svetlichnyi, S. D. Savenkov, I. A. Pshenichnov

Institutions: Russian Academy of Sciences, Institute for Nuclear Research

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Russian Science Foundation