Photoacoustic Chemical Imaging of Tumor Microenvironment pH for Prediction of Chemotherapeutic Efficacy in Breast Cancer
Year: 2025
Type: article
Abstract: studies provide evidence that clinicians can exploit this acidity by selecting drugs whose efficacy is particularly affected by the tumor microenvironment (TME). However, noninvasive measurement of tumor pH remains challenging. Photoacoustic chemical imaging enhanced by pH-sensitive nanoparticles as contrast agents is a promising technique to address this need. This imaging technique was employed to quantitatively monitor the TME pH in mice bearing patient-derived xenografts undergoing simultaneous alkalization treatment and chemotherapy. Compared to controls, in alkalinized tumors, paclitaxel chemotherapy significantly reduced tumor size, increased tumor necrosis, and reduced cancer cell proliferation as validated by histopathology and immunohistochemistry. Thus, photoacoustic chemical imaging of TME pH may provide significant predictive value and represents a promising noninvasive, reliable technology for realizing personalized cancer chemotherapy.
Source: Nano Letters
Institutions: University of Michigan, U-M Rogel Cancer Center
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G104201763, G1404790370, G1519688000, G2159916885, G4590142905, Clinical Translation of dual-modality transrectal ultrasound and photoacoustic imaging for detection of aggressive human prostate cancer, G4718633533, G7491271063, G8116573437, G9000200822, G9000240299, G9000332215, G9000334392, University of Michigan Rogel Cancer Center Support Grant 2023-2028, Role of EZH2 in Breast Cancer Progression, Detecting prostate cancer aggressiveness using photoacoustic chemical imaging with photoacoustic spectral analysis
OpenAlex ID: W4414788859