Intelligence modeling of solubility of raloxifene and density of solvent for green supercritical processing of medicines for enhanced solubility
Year: 2025
Type: article
Abstract: In this study, a dataset for solubility of raloxifene and CO 2 density was analyzed using different regression models to reveal the correlation between inputs and drug solubility via supercritical processing. The models were developed and analyzed for their accuracy in predicting the process variables. Three models of Elastic Net Regression (ENR), Orthogonal Matching Pursuit (OMP), and Gaussian Process Regression (GPR) are optimized for the dataset of drug. For CO 2 density estimation, GPR turned out to be the best R 2 , which confirmed a robust correlation. Therefore, the GPR model can be considered the most accurate and reliable for predicting CO 2 density in this context. Regarding solubility, both the ENR and OMP models demonstrated similar performance with high R 2 of 0.89062 and 0.89125, respectively. However, GPR outperformed the others with an impressive R 2 of 0.97755, a lower RMSE of 3.3221E-01, and a relatively lower AARD% of 7.08009E + 00. Hence, the GPR model is recommended for accurate solubility predictions of raloxifene. Overall, the GPR model consistently demonstrated excellent predictive performance for both CO 2 density and solubility, making it the preferred choice for modeling these relationships.
Source: Scientific Reports
Authors: Hashem O. Alsaab, Yusuf S. Althobaiti
Institution: Taif University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funder: Taif University
Awards: G1370528124, G445885861
OpenAlex ID: W4414794260