Year: 2025
Type: article
Abstract: Small non-coding RNAs known as microRNAs (miRNAs) are essential for controlling genes, and miR-21 has been shown to be a strong carcinogen in a variety of malignancies. The mechanisms of miR-21 are described in detail in this review, including the suppression of tumor suppressors like PTEN and PDCD4, the activation of pathways like PI3K/AKT, and the encouragement of aggressive phenotypes like invasion, proliferation, and resistance to treatment. Through exosomal transfer, miR-21 modifies the tumor microenvironment (TME), promoting stromal remodeling and immune suppression. Its potential as a diagnostic and prognostic biomarker is highlighted by its detectability in circulation and consistent upregulation in cancers. Anti-miR oligonucleotides and nanoparticle delivery are two therapeutic approaches that exhibit preclinical promise but struggle with specificity and clinical translation. The functions of miR-21 are summarized in this review, with a focus on novel delivery methods and standardized assays as the means of achieving its full therapeutic potential.
Authors: Farman Ullah, Faiqa Shakeel, Muhammad Ilyas, Amna Noor, Mobara Nazar, Wajiha Fatima, Zarish Noreen, Sadaf Moeez
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414796414
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