Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
Year: 2025
Type: article
Abstract: Cancer-associated cachexia is a significant contributor to poor prognosis for many cancer patients. However, mechanisms underlying cachexia associated with breast cancer are relatively understudied. This project examined mouse models of metastatic triple-negative breast cancer and found that different models exhibited varying degrees of cachexia severity, which were associated with distinct effects upon markers of protein synthesis and breakdown. Further study of these models could help to better understand the diversity of cachexia across cancer types.
Authors: Alastair A. E. Saunders, Chris Karagiannis, Wayne X. Du, Lauren S. James, Rachel E. Thomson, Robin L. Anderson, Paul Gregorevic
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414799296