Work

Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress

Year: 2025

Type: article

Abstract: Diabetic cardiomyopathy is a leading cause of death in patients with type 2 diabetes (T2D). Here, we show striking remodeling of cardiac protein secretion in mice with T2D, particularly an increase in the release of inner mitochondrial membrane proteins, which was associated with increased oxidative stress within the diabetic heart.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00073.2025

Authors: Paula M. Miotto, Jacqueline Bayliss, Gio Fidelito, James R. Bell, Lea M. D. Delbridge, Matthew J. Watt, Magdalene K. Montgomery

Institutions: The University of Melbourne, La Trobe University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Department of Health and Aged Care, Australian Government, National Health and Medical Research Council

Awards: G1141078605, G172289000, Leveraging liver-derived extracellular vesicles to identify new therapies for type 2 diabetes, G3564165575, Regulation of glycemic control by secreted modular calcium-binding protein 1, Lipid metabolism in health and disease, G6110200662, G6483474468, Discovery and validation of biomarkers for nonalcoholic steatohepatitis and liver fibrosis, G6671142144

OpenAlex ID: W4414800290

FWCI: 0.508

Cites: 65

Cited by: 2

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