Year: 2025
Type: article
Abstract: Ribonucleoprotein (RNP) condensates, such as stress granules (SGs) and P-bodies (PBs), are composed of dynamic RNA-protein complexes that regulate the fate of cytoplasmic mRNA. The presence of these membrane-less structures is relevant for many biological processes and is well appreciated. Various studies have highlighted the biomolecules that play a role in the assembly and dissolution of these structures. Although the mechanisms of assembly and the composition of these condensates are well understood, recent studies have revealed new insights into dissolution mechanisms (either via clearance or disassembly). This review discusses our current understanding of the disassembly mechanisms of SGs and PBs and highlights the importance of addressing condensate disassembly mechanisms in neurodegeneration and cancer.
Source: Cell Reports
Institution: Indian Institute of Science Bangalore
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: ALS Association, Department of Biotechnology, Ministry of Science and Technology, India, Department of Science and Technology, Ministry of Science and Technology, India, Indian Council of Medical Research, University Grants Commission, Indo-French Centre for the Promotion of Advanced Research, Ministry of Education, India, Servier, Science and Engineering Research Board
OpenAlex ID: W4414804788