Clostridioides difficile Bacteremia in an Elderly Female Patient After Colon Cancer Surgery
Year: 2025
Type: article
Study design: Case Report
Abstract: : Clostridioides difficile infection (CDI) is a major healthcare-associated concern, particularly in the elderly. While CDI typically manifests as toxin-mediated colitis, hematogenous dissemination leading to bacteremia is relatively rare and associated with high mortality. We report an unusual case of C. difficile bacteremia in an octogenarian female patient occurring shortly after right hemicolectomy for ascending colon adenocarcinoma. This critically ill patient presented with bloodstream infection in the ICU following surgery. Multiple risk factors converged, including advanced age, extensive colorectal surgery with mucosal disruption, malignancy, and broad-spectrum antibiotic exposure. Blood culture identification required specific anaerobic processing. Combined intravenous and high-dose oral vancomycin therapy, guided by rapid microbiological confirmation, led to successful resolution of the bacteremia. This case underscores the potential for life-threatening C. difficile bacteremia in vulnerable elderly patients post-colorectal cancer surgery, highlights the diagnostic challenges (necessitating anaerobic blood cultures), and emphasizes the critical importance of early suspicion, aggressive multimodal therapy, and meticulous antimicrobial stewardship in this high-risk population. It serves as a crucial reminder of this devastating complication. Keywords: Clostridioides difficile , bacteremia, colon cancer
Source: Infection and Drug Resistance
DOI: 10.2147/idr.s557503
Authors: Zhulan Yang, Kun Wang, Yi Liu, Xiaohong Xiang, Zhen Zhang
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,836
OpenAlex ID: W4414805286