Work

Obesity-induced cofilin1 pathway dysregulation: Possible molecular links between neuroinflammation, cognitive decline, and Alzheimer's disease biomarkers

Year: 2025

Type: article

Abstract: ) in the brain, saliva, and serum. At the systemic level, our results showed dysregulation of the gut microbiota, characterized by a ∼53 % increase in the Firmicutes: Bacteroidetes ratio in HFD-fed mice. HFD-fed mice also exhibited a significant increase in certain inflammatory and anti-inflammatory blood cytokines. Our findings suggest that active cofilin1 plays a significant role in diet-induced obesity and may become a potential therapeutic target.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2025.10.001

Authors: Amsha S. Alsegiani, Bdour Alshalawi, Kenza Alzahrani, Nourah Z. Alzoman, Aliyah Almomen

Institution: King Saud University

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400