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Continuous, in situ–targeted, ultrahigh-concentration antibiotic therapy for high-risk cardiovascular implantable electronic device infection: A rural tertiary care experience

Year: 2025

Type: article

Abstract: The use of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter-defibrillators (ICDs), has increased significantly in recent years. CIED-related infections are serious complications, occurring in up to 25% of patients undergoing two or more device replacements [1,2]. Even localized pocket infections warrant complete device system extraction per guideline recommendations. Although the overall procedural risk of CIED extraction is low (1–2%), certain patient and device characteristics—such as prolonged lead dwell time, ICD leads, and multiple comorbidities—can significantly increase procedural complexity and risk [3].

Source: HeartRhythm Case Reports

DOI: 10.1016/j.hrcr.2025.09.016

Authors: Elliot Hwang, Bhavani Anantharamakrishnan, Swecha Goel, Weijia Wang

Institutions: Marshfield Clinic, Marshfield Clinic, Marshfield Clinic

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,100