Comparative Effects of Oral Pregabalin, Intravenous Magnesium Sulphate, and Their Combination Given Preoperatively on Acute Post-thoracotomy Pain: A Double-Blinded Randomised Study
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: INTRODUCTION: Post-thoracotomy pain can lead to psychological distress and impair pulmonary function. Effective perioperative pain management is essential to prevent long-term complications. This study assesses the analgesic benefits of intravenous magnesium sulphate and preoperative oral pregabalin, both separately and in combination, in the treatment of acute post-thoracotomy pain. METHODS: Following ethical permission, 75 patients undergoing thoracotomy who were between the ages of 19 and 70 and had Physical Status II or III according to the American Society of Anesthesiologists were assigned to three groups at random: Group MP received 100 ml of normal saline supplemented with 50 mg/kg of intravenous magnesium sulphate and 300 mg of oral pregabalin, Group M received a placebo capsule and 50 mg/kg intravenous magnesium sulphate, and Group P received intravenous saline and 300 mg oral pregabalin. Intravenous infusions were given half an hour before surgery, and oral medicines were given an hour before. PRIMARY OBJECTIVE: This study aimed to compare 24-hour total morphine consumption (basal patient-controlled analgesia (PCA) infusion + patient-activated boluses) among pregabalin, magnesium sulphate, and combination groups. SECONDARY OBJECTIVES: This study aimed to compare postoperative Visual Analogue Scale (VAS) pain scores (one, two, four, six, eight, 12, 24 hours), duration of analgesia (time to first rescue), number of rescue boluses, incidence of postoperative nausea and vomiting (PONV) requiring treatment, Ramsay Sedation Scale scores, and patient satisfaction. RESULTS: Conclusion: Pregabalin and magnesium sulphate administered together prior to surgery successfully lower postoperative pain and the need for opioids in thoracotomy patients.
Source: Cureus
DOI: 10.7759/cureus.93810
Authors: Kriti Bhandari, Bharat Choudhary, Shikha Soni, Garima Karamchandani, Pranay Bhaiya, Rakesh Karnawat, Subhash Balara
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414809761