Year: 2025
Type: article
Abstract: Herein, a photoredox‐catalyzed protocol for allylamine hydrocarbamoylation under metal‐free and mild conditions is reported. The proposed method utilizes readily accessible 4‐carboxyamido Hantzsch esters as convenient substrates that deliver carbamoyl radicals upon a visible light‐mediated SET process. Their addition to various allylamines proceeds with good‐to‐excellent efficiency and with high levels of regio‐ and chemoselectivity to provide the corresponding γ‐amino acid amides.
Source: Advanced Synthesis & Catalysis
DOI: 10.1002/adsc.70148
Authors: Mariusz Zalewski, Sebastian Stecko
Institutions: Institute of Organic Chemistry, Polish Academy of Sciences
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4414810922