Work

Validating and Optimizing a Drosophila Larval Model of Parkinson’s Synucleopathy.

Year: 2025

Type: article

Abstract: larval model, we demonstrate that dopaminergic neurons exhibit pronounced vulnerability to αSyn, particularly to E46K and A53T variants. Additionally, we show that vitamin C effectively mitigates locomotor impairments, highlighting oxidative stress as a key contributor to αSyn-induced dysfunction.

Source: PubMed

DOI: 10.17912/micropub.biology.001592

Authors: Sarah Perry, Nicholas More

Institution: Austin Peay State University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health