Work

Discordance of Dual-Tracer PET/CT with Histopathology in a Grade I Pancreatic Neuroendocrine Tumor: A Diagnostic Conundrum

Year: 2025

Type: article

Abstract: Neuro endocrine tumors (NETs) demonstrate complex biology where imaging and histology can at times show discordance in a real-world scenario. We herein present a patient of grade I pancreatic NET showing atypical low somatostatin receptor expression on 68Ga-DOTATATE PET/CT (positron emission tomography/computed tomography) but intense fluorine-18-deoxyglucose (18FDG) avidity, and when interpreted together, these findings showed discordance with histopathology. The case highlights the crucial role of dual-tracer PET/CT in navigating the tumor biology and landscape of NET and the need for novel strategies to complement traditional histopathology that would enable better therapeutic decision-making.

Source: World Journal of Nuclear Medicine

DOI: 10.1055/s-0045-1812058

Authors: Sarina Shah, Keerti Sitani, Gauri Deshpande, Sandip Basu

Institutions: Bhabha Atomic Research Centre, Homi Bhabha National Institute, Tata Memorial Hospital

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414820785