Comparative survival analysis of gallbladder neuroendocrine carcinoma and adenocarcinoma following radical surgery: A secondary analysis of the multicenter Algerian GBC group study
Year: 2025
Type: article
Abstract: Background and objectives Gallbladder cancer (GBC) is the most common biliary malignancy, with adenocarcinoma (GB-ADK) being predominant. Gallbladder neuroendocrine carcinoma (GB-NEC) is rare, and its prognosis after R0 surgical resection remains unclear. This study compares survival outcomes after curative surgery between GB-ADK and GB-NEC. Methods This retrospective, multicenter national study included patients who underwent R0 resection for GBC in Algeria (2000–2021). Demographic, clinical, pathological, and treatment-related data were analysed. Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier and log-rank tests. Results Eleven centres participated and 1,061 patients were included (1,049 GB-ADK, 12 GB-NEC); incidental GBC was more frequent in the GB-ADK group (45.6% vs. 8.3%; p =0.016). CEA elevation was higher in the GB-NEC group (25% vs. 7.2%; p =0.020). GB-NEC exhibited more advanced stages and greater perineural/vascular invasion, though not statistically significant. Adjuvant chemotherapy was more frequently administered in the GB-NEC group (66.7% vs. 29.2%, p=0.008). No significant differences were observed in OS (p = 0.222) or DFS (p = 0.269) between GB-ADK and GB-NEC groups. Conclusion Despite a more aggressive presentation, GB-NEC did not show worse survival than GB-ADK after curative surgery. Larger studies are needed to confirm these results.
Source: Surgical Oncology Insight
Authors: Anisse Tidjane, Chafik Bouzid, Salah Berkane, Nabil Boudjenan Serradj, Khelifa Bendjebbar, Bouabdellah Krelil, Zineddine Djilli, Allel Sahli, Rezki Touati, Redha Bouzitouna, Smail Ammari, Omar Bafdel, Zaki Boudiaf, Nacim Ikhlef, Meriem Dehal, Ramzi Graichi, Ali Benazza, Saadoun Bendjabellah, N. Bahache, Mohand Kheloufi, Fatiha Berrebiha, Sif Islem Meharzi, Zohir Guezzen, Nadia Arbaoui, Aissam Megaache, Ahmed Boulkroun, Mustapha Taieb, Karim Cherchar, Benali Tabeti, Kamal Bentabak
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,300
OpenAlex ID: W4414823263