Work

The chronic phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: beyond skin and eyes

Year: 2025

Type: article

Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, potentially fatal drug reactions characterized by widespread blistering and separation of the skin and mucous membranes. While the immediate complications of SJS/TEN are well understood, growing awareness highlights that survivors can face lingering effects, some of which result in significant long-term health issues. Most studies on long-term effects have focused on skin and eye complications, but other internal organs, such as the respiratory and gastrointestinal systems, may also be impacted. Additionally, psychological consequences, stemming from the trauma of severe skin damage, are often seen. A thorough understanding of the chronic phase of SJS/TEN is vital for healthcare providers overseeing the care of patients recovering from the acute stage. This report describes two cases of TEN that involve long-term mucosal scarring and liver complications, showcasing the complexities of post-acute recovery in these individuals.

Source: The Sri Lanka Journal of Dermatology

DOI: 10.4038/sljd.v24i1.62

Authors: B. Thanushah, N. Thamilvannan, U. S. N. Ranmohottige, B. G. S. Ransimali

Institution: Teaching Hospital Batticaloa

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414825084