Assessment of nerve regeneration using nerve guidance conduits in inferior alveolar nerve injuries
Year: 2025
Type: article
Abstract: Injuries to the inferior alveolar nerve (IAN) often cause persistent sensory deficits and current treatment options such as autografts have limitations. Therefore, it is of interest to evaluate the role of collagen-based nerve guidance conduits (NGCs) in promoting IAN regeneration in 20 rabbits with 5 mm nerve gaps. Functional recovery was assessed by whisker movement scores, electrophysiology and histomorphometric analysis at 4, 8 and 12 weeks. Results showed significantly better outcomes in the NGC group, including higher whisker movement scores, improved CMAP amplitudes and greater axon counts compared to controls. Thus, we show that NGCs enhance structural and functional nerve recovery and represent a promising therapeutic approach for peripheral nerve repair in the maxillofacial region.
Source: Bioinformation
Institutions: Gajara Raja Medical College, KIIT University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414829073
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