NanoSeal-X: A Theoretical Design for a Phase-Aligned Multifunctional Wound Dressing Based on Chitosan–HA–Nanoparticle Composite
Year: 2025
Type: article
Abstract: Chronic wounds pose major clinical and economic challenges, especially in patients with comorbidities or impaired healing responses. This study presents NanoSeal-X™, a bioinspired multifunctional wound dressing engineered to address distinct biological demands at each phase of healing. The theoretical construct integrates a dual-layer matrix: a hyaluronic acid-based hydrogel embedded with silver nanoparticles, amoxicillin, and lidocaine, supported by a chitosan-based scaffold. Each component is strategically selected to provide hemostasis, infection control, tissue regeneration, and pain relief. This work presents a theoretical design framework to guide the development of multifunctional wound dressings. NanoSeal-X™ integrates pharmacological and bioactive components aligned with distinct healing phases, and serves as a translational scaffold for future empirical and clinical validation.
Source: .مجلة النسور للعلوم الطبية
Author: Mohammed Mahdi Salman Ghadban
Institution: Al-Nisour University College
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4414830900
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